Hotel Saint Vincent

The building at 1507 Magazine Street was constructed in 1861 to house St. Vincent's Infant Asylum, a charity orphanage primarily funded by Margaret Haughery, an Irish-immigrant baker and philanthropist whose own husband and infant child had died of yellow fever in 1830s New Orleans. (Founding dates are recorded variously as 1858, 1861, and 1862 across sources, with 1861 used by the hotel's own historical account.) Haughery directed the proceeds of her successful dairy and bakery operations to building and sustaining the asylum, which was operated by the Daughters of Charity to shelter children orphaned by recurring yellow fever and cholera epidemics.

Margaret Haughery died in 1882. Two years later, a public statue of her was erected in New Orleans—reputedly the second public monument to a woman in the United States. The Daughters of Charity continued to operate the asylum through the early 20th century, when expanding social-services infrastructure gradually superseded its original mission.

In the late 20th century the building was reopened as St. Vincent's Guest House, a low-cost lodging that retained much of the original architecture but operated with minimal restoration. In 2018-2021, the property was acquired and extensively restored by a Texas-based hospitality group, reopening in 2021 as the 75-room Hotel Saint Vincent. The renovation preserved the building's distinctive red-brick exterior and central courtyard while adding modern hospitality amenities, multiple restaurants, and a pool.

The hotel is recognized as a significant adaptive-reuse project in the Lower Garden District and has been featured in Garden & Gun, Where Y'at, and NOLA.com.