Once the Largest TB Hospital in America
1018 East Highway 116, Booneville, AR 72927
Research updated May 2026
Age
All Ages
Cost
Free
Museum admission free or donation-based; current campus operates as Booneville Human Development Center (active facility, restricted access)
Access
Wheelchair OK
Paved museum approach; the broader 900-acre campus contains some uneven historic walkways
Equipment
Photos OK
Est. 1910 · Largest US Tuberculosis Sanatorium · Pre-Antibiotic Era Medicine · National Register Historic District · Jim Crow Era Medical Segregation
The Arkansas Tuberculosis Sanatorium was established by act of the Arkansas legislature in 1909 to address the state's tuberculosis epidemic, which was particularly severe in the Mississippi Delta and Ozark regions. The site, three miles south of Booneville in Logan County, was selected for its dry mountain air and elevation — both believed to be therapeutic for pulmonary tuberculosis under the prevailing medical theories of the early 20th century.
The facility opened in 1910 with a single building and 64 beds. It expanded rapidly through the 1910s and 1920s, ultimately growing to 76 buildings across approximately 896 acres. The campus included staff dormitories, a fire station, post office, general store, chapel, laundry, water treatment plant, and independent telephone system — effectively functioning as a self-contained town. The architectural inventory reflects the evolution of tuberculosis treatment theory, with extensive south-facing porches, sleeping pavilions, and the gradual addition of more conventional hospital-style buildings as drug therapy replaced rest cure protocols after the 1940s.
Until 1931, the sanatorium served only white Arkansans. In that year, the Thomas C. McRae Memorial Sanatorium opened at Alexander, Arkansas, to treat African-American patients under separate-but-unequal Jim Crow medical infrastructure. The two facilities operated in parallel until integration of state medical facilities in the 1960s.
At its peak in the 1940s, the Booneville facility was the largest tuberculosis treatment hospital in the United States, with up to 5,000 patients in residence at a time and a staff of approximately 300. The medical staff published research that was consulted internationally, including by sanatoria in Italy. The introduction of streptomycin in the mid-1940s and subsequent antibiotic protocols in the 1950s reduced both the patient census and the typical length of stay. By the 1960s, the facility's primary patient population had shifted, and on June 30, 1973, the sanatorium officially closed.
In the years following closure, portions of the campus were repurposed by the Arkansas Department of Human Services. The active facility, the Booneville Human Development Center, continues to operate on portions of the historic campus serving adults with developmental disabilities. The historic district, listed on the National Register of Historic Places in 2006, encompasses 60 contributing buildings and the original landscape design. A museum operates in one of the surviving structures, interpreting the sanatorium's history.
Sources
The Booneville sanatorium's mortality rate during its pre-antibiotic decades — combined with the relatively young age of many patients and the long-duration residency typical of tuberculosis treatment — has produced one of Arkansas's most-cited paranormal reputations.
Reports collected by the Arkansas Tuberculosis Sanatorium Museum and by paranormal investigators who have worked with museum cooperation describe several recurring phenomena. Phantom voices and whispered laughter have been captured on audio recordings during nighttime sessions, particularly in the older patient dormitory buildings. Staff members and visitors have reported hearing footsteps following them through corridors in vacant structures, the sound stopping when they turn to look.
The scent of disinfectant — specifically the carbolic acid solution used in early 20th-century tuberculosis wards — has been reported in buildings that have stood empty for decades, where no cleaning chemicals are in current use. The smell is brief and localized, often reported in conjunction with sudden temperature drops.
Figures in pale hospital gowns have been observed in the windows of older dormitory buildings by visitors approaching from the museum side of the campus. These reports are anonymous and have not been documented under controlled conditions.
The campus's most-told account involves a particular patient ward described in archival material as Building 24, where staff in the post-closure years reported repeatedly finding doors that had been locked at the end of the previous shift standing open in the morning. The building has since been demolished, but the account persists in regional paranormal literature.
The museum approaches the paranormal reputation with measured respect, integrating evening tour programming during October while keeping its primary interpretive focus on medical history. Several published paranormal investigations have been conducted with museum permission, and the campus's reputation has appeared in regional television coverage. The active Booneville Human Development Center portions of the campus are not accessible to paranormal tourism and should not be approached.
The museum, housed in one of the surviving sanatorium buildings, interprets the institution's history from its 1909 founding through its 1973 closure. Exhibits include patient records, medical equipment, photographs, and oral histories from staff and patients. Open select hours; call ahead to confirm.
Drive the perimeter of the 900-acre former sanatorium campus, which retains many original buildings from the 1910s through 1940s. The campus is listed on the National Register of Historic Places as the Arkansas Tuberculosis Sanatorium Historic District. The active portions of the campus operate as the Booneville Human Development Center and are not open to public exploration.
Every HauntBound history is researched from documented sources. We clearly separate verified historical fact from paranormal folklore.
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